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Cecilio Valadez-Cano

Integrating Omics and Bioinformatics to Study Microbial Communities

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The co-existence of Microcoleus strains with gene variations in the anatoxin-a biosynthesis cluster can explain the different toxin profiles observed in freshwater benthic mats


Journal article


Cecilio Valadez-Cano, Adrian Reyes-Prieto, Lindsay Johnston, Yannan Huang, Hannah Morris, Lydia Zamlynny, André M. Comeau, Daniel G. Beach, Rob C. Jamieson, Janice Lawrence
Toxicon, vol. 264, 2025, p. 108461


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APA   Click to copy
Valadez-Cano, C., Reyes-Prieto, A., Johnston, L., Huang, Y., Morris, H., Zamlynny, L., … Lawrence, J. (2025). The co-existence of <i>Microcoleus</i> strains with gene variations in the anatoxin-a biosynthesis cluster can explain the different toxin profiles observed in freshwater benthic mats. Toxicon, 264, 108461. https://doi.org/10.1016/j.toxicon.2025.108461


Chicago/Turabian   Click to copy
Valadez-Cano, Cecilio, Adrian Reyes-Prieto, Lindsay Johnston, Yannan Huang, Hannah Morris, Lydia Zamlynny, André M. Comeau, Daniel G. Beach, Rob C. Jamieson, and Janice Lawrence. “The Co-Existence of ≪i≫Microcoleus≪/i≫ Strains with Gene Variations in the Anatoxin-a Biosynthesis Cluster Can Explain the Different Toxin Profiles Observed in Freshwater Benthic Mats.” Toxicon 264 (2025): 108461.


MLA   Click to copy
Valadez-Cano, Cecilio, et al. “The Co-Existence of ≪i≫Microcoleus≪/i≫ Strains with Gene Variations in the Anatoxin-a Biosynthesis Cluster Can Explain the Different Toxin Profiles Observed in Freshwater Benthic Mats.” Toxicon, vol. 264, 2025, p. 108461, doi:10.1016/j.toxicon.2025.108461.


BibTeX   Click to copy

@article{valadez-cano2025a,
  title = {The co-existence of <i>Microcoleus</i> strains with gene variations in the anatoxin-a biosynthesis cluster can explain the different toxin profiles observed in freshwater benthic mats},
  year = {2025},
  journal = {Toxicon},
  pages = {108461},
  volume = {264},
  doi = {10.1016/j.toxicon.2025.108461},
  author = {Valadez-Cano, Cecilio and Reyes-Prieto, Adrian and Johnston, Lindsay and Huang, Yannan and Morris, Hannah and Zamlynny, Lydia and Comeau, André M. and Beach, Daniel G. and Jamieson, Rob C. and Lawrence, Janice}
}

Abstract

Distinct anatoxin profiles can occur in Microcoleus-dominated benthic mats. Metagenomic data from a dihydrohomoanatoxin-a-producing mat revealed two co-occurring Microcoleus strains with variations in the anatoxin biosynthesis gene cluster. One cluster contained an anaK (F420-dependent oxidoreductase) similar to homologs from dihydroanatoxin-a-producing strains. The second contained the long anaG (polyketide-synthase) previously associated with homoanatoxin-a. Neither strain alone explained the observed toxin profile, suggesting that strain interaction contributes to the production of dihydrohomoanatoxin-a within benthic mats. 

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